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Guest hosts (December 13, 2021–March 1, 2022)
Guests: Peter Baker, Courtney Subramanian, Jeremy Bash, Neal Katyal, Don Calloway, Tim Miller
Guests: Sam Stein, Shannon Pettypiece, Heather Long, Juanita Tolliver, Bill Kristol, Jeremy Peters
Guests: Yamiche Alcindor, Barbara McQuade, Alexi McCammond, Al Franklin, Mark McKinnon, Clint Watts
Guests: Frank Figliuzzi, Peter Baker, Joyce Vance, Matthew Dowd, Eugene Robinson, Celine Gounder
Guests: Philip Rucker, A.B. Stoddard, Neal Katyal, Barry McCaffrey, Don Calloway, Susan Del Percio, Nahid Bhadelia
Guests: Peter Baker, Jonathan Karl, Cynthia Alksne Tim Miller, Aileen Marty
Guests: Carol Leonnig, Philip Rucker, Joyce Vance, Ben Rhodes, Matthew Dowd, Juanita Tolliver
Guests: Neal Katyal, Jackie Alemany, Shannon Pettypiece, Rick Stengel, Eugene Robinson, Bill Kristol
Guests: Yamiche Alcindor, Chuck Rosenberg, Malcolm Nance, Robert Gibbs, Mark McKinnon, Irwin Redlener
Guests: Ashley Parker, Sam Stein, Melissa Murray, Jeremy Bash, Victoria DeFrancesco Soto, Michael Steele
Guests: Katie Benner, Cynthia Alksne, Richard Stengel, Don Calloway, Nahid Bhadelia
Guests: Peter Baker, Courtney Subramanian, Barbara McQuade, Jen Psaki, Juanita Tolliver, Mark McKinnon
Guests: Philip Rucker, Harry Litman, Alexi McCammond, Alexandria Ocasio- Cortez Eugene Robinson, Mike Murphy
Guests: Jackie Alemany, Eugene Daniels, Jeremy Bash, Bill Kristol, David Plouffe, Irwin Redlener
Guests: Melissa Murray, Yamiche Alcindor, Ashley Parker, Michael McFaul, Susan Del Percio, Symone Sanders
Guests: Barry McCaffrey, Courtney Subramanian, Matthew Dowd, Michael Beschloss
Guests: Neal Katyal, Geoff Bennett, Shannon Pettypiece, Jeremy Bash, Al Franken, Bill Kristol
Guests: Peter Baker, Garrett Haake, Joyce Vance, Mark McKinnon, Eugene Robinson, Michael McFaul
Guests: David Plouffe, John Della Volpe
Guests: Alexi McCammond, Jonathan Greenblatt, Joyce Vance, Symone Sanders, Tim Miller, Murtaza Akhter
Guests: Victoria DeFrancesco Soto, Susan Del Percio
Guests: Barbara McQuade, Courtney Subramanian, Donna Edwards, Bill Kristol, Kavita Patel
Guests: Jackie Alemany, Joyce Vance, Peter Baker, Mike Murphy, Eugene Robinson, Robert Wachter
Guests: Phil Rucker, Alexi McCammond, Chuck Rosenberg, Juanita Tolliver, Mark McKinnon, Irwin Redland
Guests: Jeremy Bash, Michael Steele
Guest hosts (December 13, 2021–March 1, 2022)
Williams announced on the November 9, 2021, episode of The 11th Hour with Brian Williams that he would be leaving NBC News and MSNBC at the expiration of his contract the following month, after five years hosting the show and 28 years with the networks. Williams' final broadcast was December 9, on which he announced that the show would continue to air and have rotating guest hosts beginning December 13.
