Guest hosts (December 13, 2021–March 1, 2022)

Williams announced on the November 9, 2021, episode of The 11th Hour with Brian Williams that he would be leaving NBC News and MSNBC at the expiration of his contract the following month, after five years hosting the show and 28 years with the networks. Williams' final broadcast was December 9, on which he announced that the show would continue to air and have rotating guest hosts beginning December 13.