Larry has a hanging thigh growth so large that the weight of it makes his leg go numb. Cheerleader Bailee has a disappearing back bump she has named Ralph. With three complicated skin conditions, Ashley's case is considered a "skin nightmare."

Roger's case of rhinophyma is so extreme that he has difficulty breathing. The small, evenly spaced bumps all over Natalie's body are interfering with her life. Virginia thinks the equally sized lumps on her arms make her look like a football player.