Roger's case of rhinophyma is so extreme that he has difficulty breathing. The small, evenly spaced bumps all over Natalie's body are interfering with her life. Virginia thinks the equally sized lumps on her arms make her look like a football player.

Musician Kayla has itchy eczema everywhere, making it difficult to play her guitar. Juan was bullied so badly over the painful bumps he has on his neck and torso that he dropped out of high school. Teresa has a mysterious, deflating arm growth.