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Spider-Man takes on Doc Ock and his Sinister Five before they brainwash Spidey and destroy New York City.
It takes a last ditch, desperate effort for Spider-Man, Kid Arachnid, Anya and Harry to save Manhattan from the spider-monsters that the Jackal has created.
Spider-Man must find a way to stop Hobgoblin, who seems completely bent on doing whatever it takes to destroy Spider-Man.