After Cliff Steele's body is destroyed in a car crash, Dr. Niles Caulder takes him in, builds him a new body, and introduces Cliff to three other "patients" whose ailments give them superpowers. When Niles goes on an expedition, the group decides to take a day trip into the nearby town but things don't go as planned.

The group heads for Paraguay by bus to follow up a lead on the donkey. Flit teleports Larry and Cliff there and they meet the man responsible for Morden's transformation into Mr. Nobody.