While the investigation conducted by Caruso gets to the bottom and starts unraveling the secrets of the pandemic, Andrea faces a difficult choice: in order to be the Chief again he has to take some exams, but if he fails them he won't be allowed to be a doctor anymore. Carolina, who bonded so much with Riccardo during the emergency, ponders if she'd like something more from him than friendship.

Doc finds himself in direct competition with the new Chief and takes several risks, but he takes the opportunity to involve and help Agnese too, who had to leave the position of medical director and go back to being a doctor.