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In a world shaken by an epidemic of madness that spreads through speech, Murat is the only immune person. As he searches for the secret of his mysterious immunity, his "hot skull", he has to leave the safe zone and embark on an adventure within the ruins of Istanbul.
The explosion leads to a manhunt. Murat questions his connection to Haluk. After a tragedy, Murat makes a bold decision - and he won`t leave anyone behind.
AEI tightens security. Murat and Sule try to prevent the attack. Murat negotiates with Fazil. D-Day arrives for everyone, but Fazil has his own agenda.
Fazil detains Emel, Anton tries to contact Murat, and Sule must decrypt a message. Disturbed by his re-encounter with Haluk, Murat devises a risky plan.
Anton must fly under the radar, but Fazil forces his hand. Ozgur recounts the day of the fire. As Murat faces a moral dilemma, Viktor`s order arrives.
Anton searches for Murat and must confront Canan. Conflicts erupt within the Plus 1. Yasemin plays mind games with Murat. Fazil decides to punish Canan.
Murat recalls his past in the 6th Zone. Convinced of Murat`s immunity, Sule introduces him to Plus 1 researchers. The blue pills provide a lead.
Anton listens to Murat`s taped recordings. With the AEI on his tail, Murat must find a way into the 6th Zone. Anton hides a personal secret.
After an incident at the supermarket, Murat gets on Anton`s radar and has to leave his hideout in search of a lost friend presumed to be dead.