The interview continues. In the year 2022, the vampire Louis de Pointe du Lac recounts his life story to journalist Daniel Molloy. Picking up from the bloody events in New Orleans in 1940 when Louis and teen fledgling Claudia conspired to kill the Vampire Lestat de Lioncourt, Louis tells of his adventures in Europe, a quest to discover Old World Vampires and the Theatre Des Vampires in Paris, with Claudia. It is in Paris that Louis first meets the Vampire Armand. Their courtship and love affair will prove to have devastating consequences both in the past and in the future, and Molloy will probe to get to the truths buried within the memories.

Chafing at the limitations of life as a black man in 1900s New Orleans, Louis finds it impossible to resist the rakish Lestat's offer of the ultimate escape: joining him as his vampire companion. But Louis's intoxicating new powers come with a violent price, and the introduction of Lestat's newest fledgling, the child vampire Claudia, soon sets them on a decades-long path of revenge and atonement.