Starfleet must once again call on legendary Jean-Luc Picard after members of his former crew – Cristóbal Rios, Seven of Nine, Raffi Musiker, and Dr. Agnes Jurati – discover an anomaly in space that threatens the galaxy.

Picard and the crew travel back to 2024 Los Angeles in search of the "Watcher," who can help them identify the point at which time diverged. Seven, Raffi and Rios venture out into an unfamiliar world 400 years in their past, while Picard and Jurati attempt to gather information from an unlikely, and dangerous, ally.