In the final season, Jean-Luc Picard, in the year 2401, reunites with the former command crew of the USS Enterprise (Geordi La Forge, Worf, William Riker, Beverly Crusher, Deanna Troi, and Data) while facing a mysterious enemy who is hunting Picard's son.

Picard and his companions are trapped in an alternate reality by the extra-dimensional being Q as part of the ultimate trial for Picard, and must travel back to year 2024 Los Angeles to save the future of the galaxy.

Retired from Starfleet and living on his family's vineyard, Picard is drawn into a new adventure when he is visited by a synthetic "daughter" of Data, one of several new synthetic beings or "synths". Picard fights for their right to exist and gives his life to save them.