At Norfolk & Norwich University Hospital, an ambulance races to A&E with George, a non-verbal 23-year-old with a life-threatening neurological emergency. In Belfast, at the Royal Victoria Hospital A&E, 34-year-old midwife Rachel is suffering severe pain in her spine and is feared to have cauda equina syndrome after back surgery.

Police are called to Belfast's Royal Victoria Emergency Department when a female patient becomes aggressive, but Dr Rachel recognises she's suffering from a mental health crisis. Dr Orla is trying to save the life of 81-year-old Theresa who is struggling to breathe. In East London, at Newham Hospital, Dr Daniel is concerned for a man rushed in after being found unconscious in a kebab shop.

An aggressive male patient is rushed into Newham Hospital Emergency Department in East London, while shouting and swearing at doctors. Police are forced to physically restrain him, while Dr Nick and a team of clinicians try to determine what's wrong. Dr Sarah assesses 36-year-old David for a significant facial wound and swelling around his eye socket.

At Newham Hospital Emergency Department, a drunk man with knife wounds in his chest and hand refuses to cooperate, until heavy bleeding threatens his vital organs. In Belfast's Royal Victoria A&E, an 81-year-old woman has suffered a brutal injury to her leg from slipping in her muddy garden and smashing her shin into a concrete bar.

In East London, at Newham Hospital Emergency Department, doctors rush to save a 36-year-old man's sight, who has been violently attacked. Dr Rosie cares for a 63-year-old woman with a significant head injury in Newham. In Belfast, Dr Alice runs urgent tests to assess 83-year-old farmer Ian, who is suffering from suspected life threatening abdominal pain.

In East London, at Newham Hospital A&E, a man suspected of being intoxicated causes a disruption and shouts at the nurses, causing a delay for other patients. A homeless woman is rushed to the hospital's resus department, after she was found collapsed in the street. At Belfast's Royal Victoria Hospital, nurse Rebekah deals with a man who has taken a cocaine overdose.

In Newham, doctors struggle to deal with an abusive man who claims he's swallowed a pack of heroin, while a 17- year-old is rushed to A&E after vomiting blood after a tonsillectomy.

In Belfast's Royal Victoria A&E, an intoxicated woman complains loudly that she should be seen first before any foreigners and becomes increasingly aggressive. Twenty-one-year-old Roberta is in agony after dislocating her shoulder from a fall at home. A 27-year-old is rushed to Newham Hospital, East London, after her throat began to swell and close up while out drinking with her friends.

At Norfolk and Norwich University Hospital a man has been rushed in by ambulance after a stabbing. The police are very keen to speak to him, but the patient is refusing to cooperate, causing a huge disturbance in A&E. No sooner has the victim's treatment begun when another ambulance brings in the knife-wielding attacker. Dr Claire and nurse Jessica fight to save both their lives.