It's all systems go, with paramedics racing to the scene of a nasty motorbike and sidecar crash; a call comes in for a woman who has fallen off her balcony while trying to retrieve her friend's cat.

In Brisbane, a bystander calls in a crash in the heart of Brisbane CBD, involving a motorcyclist and taxi. Paramedics arrive to find patient Hector face down on the road, not moving.

A crash on a busy intersection sees a severely broken leg front and centre, but paramedics fear the patient may also have spinal cord injuries. Plus, a patient suffers from potentially deadly sepsis.

Paramedics Jeff and Tamara are called to help 92-year-old Ray, who is pinned under his mobility scooter after it tipped over, and then attend to a baby who is turning blue and struggling to breathe.

When a head-on collision leaves one driver trapped in their car, Tash, a specialist Critical Care Paramedic, is faced with a difficult decision to try and save the woman's life.

The low blood sugar levels of 23-year-old type one diabetic have led to a dangerous seizure. Another code 1A comes in for two-year-old Levi, suffering serious respiratory issues.

Tonight, a man claims to have jumped off Brisbane's Story Bridge and we see the effects this has on the professionals who are racing to piece together a puzzle to try and save a life.

In tonight's season premiere, we follow Shane & Shelly, who must help a patient in need of urgent care after an incident involving a car. It's classified as a code 1A, the most serious emergency.