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When Sam is unable to sleep and won't leave the bunker, Dean suggests that they look into the case of a retiree who bashed his head in while yelling that he could hear someone screaming.
Lucifer takes Sam on a trip through Sam's memories to convince him to agree to possession. Meanwhile, Castiel goes to determine if Amara is dead, and Dean and Crowley come up with a plan to send Lucifer back to his cage.
Sam and Dean pay a visit to Jody after one of her wards, Claire Novak, calls them and insists that there are monsters in their town. A corpse soon turns up, and Jody and the Winchesters realize that Claire was right.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?