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Lucifer takes Sam on a trip through Sam's memories to convince him to agree to possession. Meanwhile, Castiel goes to determine if Amara is dead, and Dean and Crowley come up with a plan to send Lucifer back to his cage.
While Sam enters Hell with Crowley and Rowena to confront Lucifer and seek his help defeating Amara, Dean investigates the scene of Amara's recent killing and discovers that she has plans for him.
When Sam is unable to sleep and won't leave the bunker, Dean suggests that they look into the case of a retiree who bashed his head in while yelling that he could hear someone screaming.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?