Sam and Dean take a break from looking for Amara to check out a case of a girl going into a coma. They soon discover that their case is connected to a similar case that Bobby and Rufus investigated several years ago... and never completely solved.

Sam and Dean try to convince Crowley to turn over the Horn of Joshua before destroying Lucifer--and Castiel--rather than after they use the Horn to defeat Amara. Meanwhile, an unexpected ally helps Amara heal from her injuries, and Lucifer makes the angels in Heaven an offer they can't refuse.