Donatello, the newest Prophet of God, senses God's power and comes looking for him. Meanwhile, a Lord of Hell decides to use Jack to unleash the foulest beasts of Hell. In the other universe, Lucifer and Mary meet the angels including the one who killed "his" Lucifer.

Two people turn up dead, apparently killed by their deceased love ones. Sam convinces Dean to take Jack with them on the case, and they discover that both victims were seeing a grief counsellor, Mia Vallens. Meanwhile, Castiel meets the keeper of the void that he's trapped in.