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The four survivors begin manifesting strange symptoms, but Eph and Nora's attempt to quarantine them is thwarted as the disinformation campaign begins. Setrakian receives a surprise visit from an old – a very old – acquaintance.
When a plane lands in New York City with everyone on board dead, Dr. Ephraim 'Eph' Goodweather, head of the CDC's Canary Project, and his team are called upon to investigate. What looks at first like a mysterious viral outbreak might be the beginning of something infinitely more sinister
Eph and Nora fight to save Captain Redfern's life before coming face-to-face with the horrifying effects of the virus. A spike in rat attacks signals Fet that something inexplicable is happening deep below the city. Released from jail, Setrakian begins his own merciless plan to stop the spread of the disease.
A plane lands at John F. Kennedy International Airport with lights off and doors sealed. Epidemiologist Dr. Ephraim Goodweather and his team are sent to investigate. On board they find two hundred corpses and four survivors. The situation deteriorates when the bodies begin disappearing from morgues. Goodweather and a small group of helpers find themselves battling to protect not only their own loved ones, but the entire city, from an ancient threat to humanity.