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A plane lands at John F. Kennedy International Airport with lights off and doors sealed. Epidemiologist Dr. Ephraim Goodweather and his team are sent to investigate. On board they find two hundred corpses and four survivors. The situation deteriorates when the bodies begin disappearing from morgues. Goodweather and a small group of helpers find themselves battling to protect not only their own loved ones, but the entire city, from an ancient threat to humanity.
Eph and Fet recon for an all-out assault that Setrakian assures them will finally kill the Master. Gus aligns himself with a strange new force, one that may swing the fight in an unforeseen direction.
Dutch returns with a plan to broadcast Eph's warning about the vampiric plague, but they face a new threat when Eichhorst launches his own attack against the pawn shop. Palmer receives a special visitor. Gus gears up for the on-coming fight but discovers there's another mysterious factor involved.
Setrakian leads Eph, Fet and Nora in the hunt for the Master's lair. Left behind at the pawnshop with Mariela, Zack risks his safety for Mariela's sake.
Eph investigates Kelly's disappearance and struggles with what he finds. Dutch pursues a plan to retaliate against Palmer. Fitzwilliam makes a surprising choice.
Eph races to safeguard his family, only to learn that Kelly is missing. Dutch reveals her role in Palmer's plan. Gus is forced to make a difficult decision about Felix.
After discovering the potency of ultraviolet light against the strigoi, Setrakian gains a new and unlikely disciple. A quick trip to a Brooklyn convenience store turns into a deadly all-night siege.
Setrakian, Eph and Nora formulate a plan to track down the Master using Jim as bait. Eichhorst and Setrakian's pasts are revealed. At the Luss home, Neeva struggles to protect the children while encountering a mysterious stranger whose help she may not want.
After warning Kelly to leave the city with Zack ahead of the spreading plague, Eph is arrested by the FBI. Eichhorst has one final job for Gus. Setrakian realizes that the coming eclipse is the tipping point for virus infection and the beginning of the end
With Nora gone, Eph reluctantly joins Setrakian's quest in hopes of gathering enough evidence to warrant a citywide quarantine. Fet encounters the unexpected inside the subway tunnels. A medical emergency threatens Palmer's master plan.
A secret autopsy demonstrates the bizarre progression of the mystery virus, prompting Jim to make a startling confession. Eph and Nora race to find the father of the youngest victim of the plane tragedy, but someone unexpected beats them to it. Ansel, in the grip of disease, takes desperate measures to protect his family.
Eph and Nora fight to save Captain Redfern's life before coming face-to-face with the horrifying effects of the virus. A spike in rat attacks signals Fet that something inexplicable is happening deep below the city. Released from jail, Setrakian begins his own merciless plan to stop the spread of the disease.
The four survivors begin manifesting strange symptoms, but Eph and Nora's attempt to quarantine them is thwarted as the disinformation campaign begins. Setrakian receives a surprise visit from an old – a very old – acquaintance.
When a plane lands in New York City with everyone on board dead, Dr. Ephraim 'Eph' Goodweather, head of the CDC's Canary Project, and his team are called upon to investigate. What looks at first like a mysterious viral outbreak might be the beginning of something infinitely more sinister
As the fourth and final season begins, nine months have passed. The world has fallen into darkness, and the strigoi are in control. The explosion at the end of season three triggered a global nuclear apocalypse. The resulting nuclear winter liberated the strigoi, allowing them to move about during daytime, and allowing the Master to establish a totalitarian regime. Preying on the fears of the populace, the Master and his minions have created an unsettling alliance in "The Partnership." The majority of humans are now working for the strigoi, operating with a single understanding -- collaborate or die. With the world in disarray and our heroes disbanded, each of them will have to overcome personal hardship and defy death for even the smallest chance at fighting back... All the while, the Master reigns supreme, furthering his scheme for the end of the world as we know it. In the face of annihilation...do our heroes have what it takes to save humankind?
As season three begins, New York City is a battleground. Written off by the federal government, the people of New York City must fight for survival on their own. The question is who will win? Humans or strigoi? Our heroes win victories, but are not winning the war. Beset by personal conflicts – betrayal, disappointment, paranoia – our group is splintering… Meanwhile, the Master is close to executing an irreversible transformation of the world. Is there still hope to save the city and humanity?
The virus has reached epidemic levels in season two as the Master seeks revenge. Eph and Dr. Nora Martinez work on a weapon to destroy the creatures, while Abraham Setrakian searches for a book that may hold the secrets to ending the infected.
A plane lands at John F. Kennedy International Airport with lights off and doors sealed. Epidemiologist Dr. Ephraim Goodweather and his team are sent to investigate. On board they find two hundred corpses and four survivors. The situation deteriorates when the bodies begin disappearing from morgues. Goodweather and a small group of helpers find themselves battling to protect not only their own loved ones, but the entire city, from an ancient threat to humanity.