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Eph and Fet recon for an all-out assault that Setrakian assures them will finally kill the Master. Gus aligns himself with a strange new force, one that may swing the fight in an unforeseen direction.
Dutch returns with a plan to broadcast Eph's warning about the vampiric plague, but they face a new threat when Eichhorst launches his own attack against the pawn shop. Palmer receives a special visitor. Gus gears up for the on-coming fight but discovers there's another mysterious factor involved.
A plane lands at John F. Kennedy International Airport with lights off and doors sealed. Epidemiologist Dr. Ephraim Goodweather and his team are sent to investigate. On board they find two hundred corpses and four survivors. The situation deteriorates when the bodies begin disappearing from morgues. Goodweather and a small group of helpers find themselves battling to protect not only their own loved ones, but the entire city, from an ancient threat to humanity.