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Before he has Quinlan kill him, Abraham tells the others how to defeat the Master. They begin by assaulting the Partnership facility and capturing Desai. Meanwhile, the Master sends Zack on a special mission.
Eph reunites with Abraham and Dutch, bringing Alex along with him. His health failing, Setrakian ignores Eph's warnings, pushing himself to the limit in his quest for victory and revenge. Fet and Quinlan race back to Manhattan. Meanwhile, Gus decides to help the resistance, but Creem goes to the Master with valuable information. Later, the Master seals off the city and prepares to eliminate them all.
The team threatens Selah to get leverage against Desai. Meanwhile, Eph tries to determine if Zack is working for the Master or not, while Gus goes to recover the nuke.
As the fourth and final season begins, nine months have passed. The world has fallen into darkness, and the strigoi are in control. The explosion at the end of season three triggered a global nuclear apocalypse. The resulting nuclear winter liberated the strigoi, allowing them to move about during daytime, and allowing the Master to establish a totalitarian regime. Preying on the fears of the populace, the Master and his minions have created an unsettling alliance in "The Partnership." The majority of humans are now working for the strigoi, operating with a single understanding -- collaborate or die. With the world in disarray and our heroes disbanded, each of them will have to overcome personal hardship and defy death for even the smallest chance at fighting back... All the while, the Master reigns supreme, furthering his scheme for the end of the world as we know it. In the face of annihilation...do our heroes have what it takes to save humankind?