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While Vasiliy and Quinlan try to obtain a nuclear warhead, Eph leads a strike against the strigoi in Philadelphia... alerting the Master and Eichhorst to his presence. Meanwhile, Zack makes a new friend.
The fates of Gus and Dutch are revealed, while Eph continues to help Alex and her brother.
Desai forces Dutch to help him calm down a woman undergoing C-section. Meanwhile, the underground takes a heavy blow and Eph and Alex learn of New Horizons.
As the fourth and final season begins, nine months have passed. The world has fallen into darkness, and the strigoi are in control. The explosion at the end of season three triggered a global nuclear apocalypse. The resulting nuclear winter liberated the strigoi, allowing them to move about during daytime, and allowing the Master to establish a totalitarian regime. Preying on the fears of the populace, the Master and his minions have created an unsettling alliance in "The Partnership." The majority of humans are now working for the strigoi, operating with a single understanding -- collaborate or die. With the world in disarray and our heroes disbanded, each of them will have to overcome personal hardship and defy death for even the smallest chance at fighting back... All the while, the Master reigns supreme, furthering his scheme for the end of the world as we know it. In the face of annihilation...do our heroes have what it takes to save humankind?