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Coulson and his team find themselves without anyone they can trust, only to discover that they are trapped with a traitor in their midst.
Agents Garrett and Triplett are back to help Coulson's team track down S.H.I.E.L.D.'S nefarious enemy - the Clairvoyant. But will Deathlok destroy them all to protect his master's identity?
With Colonel Glenn Talbot now on their trail, Coulson and his team seek refuge in the last place anyone would look, where they begin to uncover S.H.I.E.L.D.'s most dangerous secrets -- secrets that could destroy them all.
Set after the events of the Battle of New York, S.H.I.E.L.D. Agent Phil Coulson assembles his own team of skilled agents and operatives including Melinda May, Grant Ward, Leo Fitz, Jemma Simmons, and newly-recruited Skye investigate several dangerous cases including the Project Centipede and its leader, The Clairvoyant, while Coulson also searches for answers surrounding his mysterious resurrection.