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Daisy and Melinda escape the Triskelion and go on the run from Hydra. Meanwhile, Jemma realizes what Aida has planned, and Holden tells Alistair who he is in the real world.
Coulson and Jeffrey break into an Enlightenment Center to rescue a prisoner with valuable information about Project Looking Glass. Meanwhile, Fitz meets with an unexpected ally, and Jemma tries to convince Grant and Jeffrey that their world isn't real.
Daisy and Jemma take the team to the backdoor, only to discover that Aida has anticipated them. Meanwhile, Fitz discovers that his father is dead and who is responsible, and sets out to exact vengeance.
The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords.