Aida sets out to destroy the world with the help of the Darkhold, and only Ghost Rider can stop her. Meanwhile, S.H.I.E.L.D. is framed for weaponizing the Inhumans and the authorities close in on the team.

While Coulson and Melinda try to escape the rig, Jemma and Daisy find themselves under attack. Meanwhile, Aida revels in the joys of becoming human.

Daisy and Jemma take the team to the backdoor, only to discover that Aida has anticipated them. Meanwhile, Fitz discovers that his father is dead and who is responsible, and sets out to exact vengeance.

Daisy and Melinda escape the Triskelion and go on the run from Hydra. Meanwhile, Jemma realizes what Aida has planned, and Holden tells Alistair who he is in the real world.

Coulson and Jeffrey break into an Enlightenment Center to rescue a prisoner with valuable information about Project Looking Glass. Meanwhile, Fitz meets with an unexpected ally, and Jemma tries to convince Grant and Jeffrey that their world isn't real.

While Daisy tries to get Holden's location via Hydra's databases, Coulson and Jemma meet with the head of the resistance. Meanwhile, Aida tells Fitz her version of the truth about the Framework.

Jemma and Daisy discover that things have gone horribly wrong in the Framework, when they realize that Hydra now rules the world and ruthlessly hunts down and exterminates Inhumans.

Fitz and Jemma realize that they may be the only senior staff that haven't been replaced with LMDs. Meanwhile, Aida makes her own plans to protect the Framework.

The team follows a series of clues left by the Superior designed to bring them to their opponent's base... and the trap that he's set for them.

The Superior sends Terrence to trigger Terragenesis in Nadeer, believing that she's an Inhuman. However, they all got an explosive surprise. Meanwhile, Coulson and Mack track down the woman that Aida's appearance was based on and try to use her to find Melinda.

The Superior and his men abduct Billy Koenig to get the location of the Darkhold from him. While Coulson and his field team go after Sam, Fitz, Jemma, and Mack deal with the Holden LMD that they captured.

Coulson authorizes a mission to bug Nadeer's office against Talbot's advice, but things go bad. Meanwhile, Holden finds the key to keeping Melinda imprisoned, and Fitz finds out what his friend is up to.

After an attempt on Jeffrey's life, Coulson and Mack escort him to safety... and discover the secret of his Inhuman abilities. Meanwhile, Fitz promises the decapitated Aida that he'll try to restore her, and Melinda wakes up in Holden's apartment.

Jemma confirms Vijay's identity, and she, Jeffrey, and Daisy go to rescue him from his sister and the Watchdogs. Meanwhile, Aida attacks S.H.I.E.L.D. HQ in an attempt to obtain the Darkhold.

When Eli creates a nuclear bomb using his new powers, Fitz realizes where he is getting his energies from... and that they threaten to destroy LA. The team has to take Eli down before it's too late, but Eli manages to take Ghost Rider out of commission.

Coulson, Fitz, and Robbie disappear and their teammates assume that they're dead... unaware that they're out of phase, intangible, and invisible. Meanwhile, Mack loses hope and the vengeance demon seeks a now host.

How Robbie became Ghost Rider is revealed, after Jeffrey boards the Quinjet looking for Robbie and Daisy. Meanwhile, Lucy forces Eli to reveal the secrets of the Darkhold.

Coulson and his people break into prison to free Eli before Lucy finds him. Meanwhile, Jeffrey goes before the nation to debate Senator Nadeer about the Inhuman issue.

Daisy turns to Jemma for help, while Mack and Coulson pay a visit to Robbie's uncle Eli and encounter Ghost Rider. Meanwhile, Holden and Fitz use Melinda to test to see if Aida can pass as human.

A group claiming to be the Inhumans Resistance launches a series of blackouts across the globe. Jeffrey suspects something more is going on and sends Coulson, Mack, and Fitz to investigate. Meanwhile, Daisy learns more about Robbie and his brother Gabe, and Jemma and Holden struggle to save Melinda's life.

Daisy tracks down Robbie and demands answers. Meanwhile, Fitz and Mack get a lead on the ghost that emerged from the box, and discover that there are more than one.

After the Sokovia Accords, S.H.I.E.L.D. is under new management. Jemma is advising the new Director, Coulson and Mack are in the field, Melinda is training an elite strike force, and Daisy has gone rogue taking down Watchdog resources. She comes across a mysterious serial killer known as "Ghost Rider" who is apparently the Spirit of Vengeance.... and will stop at nothing to get his grisly revenge.