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Daisy turns to Jemma for help, while Mack and Coulson pay a visit to Robbie's uncle Eli and encounter Ghost Rider. Meanwhile, Holden and Fitz use Melinda to test to see if Aida can pass as human.
A group claiming to be the Inhumans Resistance launches a series of blackouts across the globe. Jeffrey suspects something more is going on and sends Coulson, Mack, and Fitz to investigate. Meanwhile, Daisy learns more about Robbie and his brother Gabe, and Jemma and Holden struggle to save Melinda's life.
Coulson and his people break into prison to free Eli before Lucy finds him. Meanwhile, Jeffrey goes before the nation to debate Senator Nadeer about the Inhuman issue.
The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords.