After the Sokovia Accords, S.H.I.E.L.D. is under new management. Jemma is advising the new Director, Coulson and Mack are in the field, Melinda is training an elite strike force, and Daisy has gone rogue taking down Watchdog resources. She comes across a mysterious serial killer known as "Ghost Rider" who is apparently the Spirit of Vengeance.... and will stop at nothing to get his grisly revenge.

A group claiming to be the Inhumans Resistance launches a series of blackouts across the globe. Jeffrey suspects something more is going on and sends Coulson, Mack, and Fitz to investigate. Meanwhile, Daisy learns more about Robbie and his brother Gabe, and Jemma and Holden struggle to save Melinda's life.