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While Coulson and Melinda try to escape the rig, Jemma and Daisy find themselves under attack. Meanwhile, Aida revels in the joys of becoming human.
Daisy and Jemma take the team to the backdoor, only to discover that Aida has anticipated them. Meanwhile, Fitz discovers that his father is dead and who is responsible, and sets out to exact vengeance.
Aida sets out to destroy the world with the help of the Darkhold, and only Ghost Rider can stop her. Meanwhile, S.H.I.E.L.D. is framed for weaponizing the Inhumans and the authorities close in on the team.
The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords.