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When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is in charge of the kids. Also, Sheldon finds a book on experimenting on kids, and the guys plus Amy make a day of it.
When the gang finds out Wil Wheaton hosts a celebrity Dungeons and Dragons game involving William Shatner, Joe Manganiello, Kareem Abdul-Jabbar and Kevin Smith, deception and betrayal are the path to make it to the one open seat.
When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to bring Nobel laureates Kip Thorne, George Smoot and Frances Arnold to their side. Also, Halley's fear of the dark leads to opportunity and conflict for Howard, Bernadette and Stuart.