Penny tries to seduce an abstaining Leonard to ruin his "donation" for her ex-boyfriend, Zack, and his wife, Marissa. Also, Wolowitz, Bernadette, Anu and Koothrappali turn Koothrappali's canceled bachelor party into a couple's trip aboard the "vomit comet".

When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is in charge of the kids. Also, Sheldon finds a book on experimenting on kids, and the guys plus Amy make a day of it.