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A wealthy donor to the university makes Leonard consider how far he's willing to go for the sake of science.
Sheldon hopes acting lessons from Penny will help him become a better teacher. Meanwhile, Koothrappali fantasizes about his best friend's girlfriend.
As Wolowitz contemplates taking things with Bernadette to the next level, Leonard rekindles his relationship with Raj's sister.
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.