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Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
When Bernadette receives her Ph.D., the guys take joy in reminding an emasculated Wolowitz that he is the only one in their group who isn't a doctor. Meanwhile, Koothrappali becomes Sheldon's new roommate after hearing Leonard and Priya engaging in a "Star Trek" bedroom fantasy.
When Howard finally breaks the news to his mom that he's engaged to Bernadette, it lands her in the hospital.
Raj attempts to cure his social anxiety disorder while Penny uses Bernadette to spy on Leonard and his girlfriend.
When Priya uses her lawyer skills to pick apart the roommate agreement, the girls take Sheldon dancing.
Sheldon and Amy experiment on their friends by spreading gossip, while Howard takes a big step in his relationship with Bernadette.
When someone hacks Sheldon's online game account, the guys go on a quest to find the culprit.
Leonard must choose between new girlfriend Priya and his friendship with Penny. Meanwhile, Howard drives Sheldon crazy with a magic trick.
Sheldon struggles to cope when he realizes it's actually Leonard who is the center of their social group.
As Wolowitz contemplates taking things with Bernadette to the next level, Leonard rekindles his relationship with Raj's sister.
A wealthy donor to the university makes Leonard consider how far he's willing to go for the sake of science.
Sheldon hopes acting lessons from Penny will help him become a better teacher. Meanwhile, Koothrappali fantasizes about his best friend's girlfriend.
Tension runs high when everyone is staying at the same hotel for a science event and Bernadette runs into her ex-boyfriend.
Leonard's idea for a smartphone app derails his friendship with Sheldon.
The guys find a "super" use for Penny's new boyfriend, Zack, when they enter a costume contest as the Justice League.
Amy finds she has sexual feelings for Penny's ex, while Koothrappali and Wolowitz try to prove who would be the better superhero.
Penny asks Leonard to lie to her father, while Howard, Raj and Bernadette pull an all-nighter at a telescope.
While the guys camp in line for a screening, Penny and Bernadette invite Amy to her first slumber party.
Sheldon's answers during an FBI interview put Wolowitz's security clearance in jeopardy.
Leonard keeps an affair secret from Sheldon, Howard and Raj.
Leonard realizes he's the only one without a girlfriend, while Sheldon wants to get rid of his.
An embarrassing secret of Wolowitz's comes to light, while Sheldon and Raj have a small war at work.
The guys are concerned as Sheldon searches for an alternative to human companionship.
Sheldon realizes he won't live long enough to download his consciousness into a robot body, and attempts to extend his lifespan.
Penny finds herself along for the ride on Sheldon's first date ever; while Wolowitz finds a new use for a robotic arm.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
Penny regrets her sleeping with Raj and has become very good friends with Leonard, Leonard breaks up with Priya, Amy pushes Sheldon in their relationship eventually becoming boyfriend and girlfriend, Penny and the other women become a clique of their own, Howard prepares for his wedding and going into space to the International Space Station and Leonard asks Penny out as they begin "Leonard and Penny 2.0".
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
Penny throws herself at Leonard after he returns from three months at the North Pole and they begin a relationship, Penny and Sheldon start a quirky friendship though she can still annoy him, Howard begins to date Bernadette Rostenkowski and Sheldon meets Amy Farrah Fowler.
Leonard and Penny's relationship takes a turn for the worse when they break up, but is quickly resolved. Soon their relationship progresses into a stronger friendship than before, while Sheldon and Penny's friendship slowly begins.
The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.
