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Tension runs high when everyone is staying at the same hotel for a science event and Bernadette runs into her ex-boyfriend.
Leonard's idea for a smartphone app derails his friendship with Sheldon.
Sheldon hopes acting lessons from Penny will help him become a better teacher. Meanwhile, Koothrappali fantasizes about his best friend's girlfriend.
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.