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When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. Meanwhile, in space, the other astronauts pick on Howard.
With his friends on dates, Raj must face his loneliness. Also, Wolowitz is caught in an argument between Bernadette and his mom, even while he's in space.
Amy feels threatened when Sheldon hires a young female assistant, and the pressure of being in space takes its toll on Wolowitz.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.