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Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
New success for Leonard makes Sheldon very jealous and throws Penny for a loop. Meanwhile, Koothrappali pushes Lucy too far in their relationship.
When the girls' trip to Vegas falls through, the guys invite them to play Dungeons & Dragons, causing Sheldon and Amy's relationship to take an unexpected turn. Meanwhile, Koothrappali and Lucy go on a very awkward date.
Sheldon and Leonard hire Professor Proton, the host of their favorite childhood TV show, to perform. Also, Howard and Bernadette run into trouble babysitting Raj's dog.
Sheldon feels lost after one of his favorite TV shows gets canceled too soon and Amy tries to help him get over his compulsive need for closure. Meanwhile, Raj discovers a secret about his new love interest, Lucy.
Leonard, Sheldon and Raj fight for tenure at the University, and the competition heats up when the girls get involved.
Howard struggles with whether or not he should open a letter from his father, and Leonard and Penny throw a "grown-up" cocktail party at the apartment.
Leonard, Sheldon and Wolowitz speak to junior high girls about careers in science. Meanwhile, Koothrappali plans a date with Lucy.
After a terrible date, Koothrappali vows to never leave his apartment. Meanwhile, Penny actually impresses Sheldon with her acting skills.
While the guys try to give their significant others the perfect Valentine's Day, Raj and Stuart throw a "lonely people" party at the comic book store.
When Sheldon and Leonard fight, it affects Penny and Amy's living arrangements. Meanwhile, Raj takes care of Mrs. Wolowitz while Howard is away.
Sheldon is forced to work with Barry Kripke and faces a crisis of confidence. Meanwhile, Howard and Raj spend $1,000 on action figures of themselves.
While the guys take a road trip to a comic book convention dressed as "Star Trek: The Next Generation" characters, the girls stay home and try to interpret a comic book.
Sheldon gets accused of sexual harassment at the University and winds up getting Leonard, Raj and Wolowitz in trouble.
Sheldon revisits some Christmas memories during a game of Dungeons and Dragons, while Penny, Bernadette and Amy try to find a girl for Koothrappali when he joins the girls for ladies' night.
Sheldon tries to nurse a sick Amy back to health, while Wolowitz prepares for an upcoming fishing trip with his father-in-law.
When the University reassigns Sheldon's parking spot to Wolowitz, their fight affects the whole gang.
Howard and Raj try to get to the bottom of why Sheldon disappears every afternoon at 2:45. Meanwhile, Leonard and Penny deal with jealousy in their relationship.
Wolowitz struggles with moving out of his mother's house. Meanwhile, Sheldon is caught in the middle of an argument between Amy and Wil Wheaton.
Sheldon's relationship with Stephen Hawking is threatened over a game of "Words with Friends," and Penny secretly enrolls in a class at the local college.
The gang celebrates Halloween at Stuart's comic book store. Meanwhile, Leonard seduces Penny with science.
When Wolowitz returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.
Amy feels threatened when Sheldon hires a young female assistant, and the pressure of being in space takes its toll on Wolowitz.
When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. Meanwhile, in space, the other astronauts pick on Howard.
With his friends on dates, Raj must face his loneliness. Also, Wolowitz is caught in an argument between Bernadette and his mom, even while he's in space.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
Penny regrets her sleeping with Raj and has become very good friends with Leonard, Leonard breaks up with Priya, Amy pushes Sheldon in their relationship eventually becoming boyfriend and girlfriend, Penny and the other women become a clique of their own, Howard prepares for his wedding and going into space to the International Space Station and Leonard asks Penny out as they begin "Leonard and Penny 2.0".
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
Penny throws herself at Leonard after he returns from three months at the North Pole and they begin a relationship, Penny and Sheldon start a quirky friendship though she can still annoy him, Howard begins to date Bernadette Rostenkowski and Sheldon meets Amy Farrah Fowler.
Leonard and Penny's relationship takes a turn for the worse when they break up, but is quickly resolved. Soon their relationship progresses into a stronger friendship than before, while Sheldon and Penny's friendship slowly begins.
The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.
