Leonard and Amy help Sheldon cope with the shame he's feeling after his accidental contribution to science is disproved. Meanwhile, Raj must stay with Howard and Bernadette for a week.

When Penny's big acting break on NCIS is a bust, Leonard struggles to help her, which results in Penny asking Leonard a bold relationship question. Meanwhile, Sheldon tries to learn how to be funny and Raj tries to work on his "game" before talking to girls.