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Sheldon tries to relax after he is forced to take a vacation. Meanwhile, Leonard struggles to be supportive of Penny after she quits her job, and Bernadette seeks Stuart's help in replacing one of Howard's comic books.
When Penny's big acting break on NCIS is a bust, Leonard struggles to help her, which results in Penny asking Leonard a bold relationship question. Meanwhile, Sheldon tries to learn how to be funny and Raj tries to work on his "game" before talking to girls.
After the guys can't get Comic-Con tickets, Sheldon tries to hold his own convention and winds up spending a wild night with James Earl Jones. Meanwhile, the girls see if they can act like "grown-ups".
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.