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After his workers defect to the Mormons, Cullen recruits Durant to help get them back. Meanwhile, Sean and Mickey's past comes back to haunt them.
A cholera epidemic in Hell on Wheels has Cullen seeking fresh water to help save his workers. Meanwhile, Durant faces political fallout.
With Gen. Grant's deadline looming, a gang of riders attacks Cheyenne while Cullen and Elam pay Durant a visit.
Bohannon abandons seeking revenge for the deaths in his family in order to battle Durant for control of the Union Pacific Railroad. Eva gives birth to a baby that was sired during her marriage to Gregory Toole. Elam proposes marriage to her, even though her post-partum depression weighs heavily on her. The Swede takes up with a Mormon family on their way to Fort Smith and later reveals his true nature.