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A cholera epidemic in Hell on Wheels has Cullen seeking fresh water to help save his workers. Meanwhile, Durant faces political fallout.
Cullen's position is threatened after Durant files an injunction against the Union Pacific. Meanwhile, Elam deals with a dangerous newcomer.
After his workers defect to the Mormons, Cullen recruits Durant to help get them back. Meanwhile, Sean and Mickey's past comes back to haunt them.
Bohannon abandons seeking revenge for the deaths in his family in order to battle Durant for control of the Union Pacific Railroad. Eva gives birth to a baby that was sired during her marriage to Gregory Toole. Elam proposes marriage to her, even though her post-partum depression weighs heavily on her. The Swede takes up with a Mormon family on their way to Fort Smith and later reveals his true nature.