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Carrie is unable to utilize her perfect memory when an assassin doses her with a deadly poison that attacks her brain, leaving Al on a desperate hunt for the antidote.
Carrie and Al delve into the disturbing - and dangerous - world of celebrity obsession when a television star is found murdered in his dressing room.
Carrie and Al investigate the murder of a high-end matchmaking service employee, but each secret they uncover in the victim's life only serves to create a new possible suspect and motive.
When Homeland Security takes over a bombing investigation from Major Crimes, Carrie doubts their conclusion that it's tied to terrorism and secretly continues her own investigation. Meanwhile, Webster makes friends with Murray's daughter.
Carrie and Al dig into the secrets of students and faculty at an elite prep school when a high-powered CEO and father of one of the students is murdered.
Carrie and Al's investigation into the death of a college dropout takes a surprising turn when they discover he had been living in an off-the-grid community on an abandoned island near Manhattan.
When one of Eliot's oldest friends, the campaign manager for a mayoral candidate, is murdered, he is forced to face his past and current demons as Carrie and Al work to uncover the killer.
Al becomes the prime suspect in the murder of a parolee he helped put in jail, forcing Carrie to conduct an off-the-books investigation to prove his innocence to Internal Affairs.
Carrie and Al must find the connection between a murdered coast guard officer, a celebrity chef who threw him out of his restaurant and a missing block of C-4 before the explosives are used.
When Carrie recognizes a murdered city official as someone she played poker with at an underground casino, she puts her career on the line by admitting her illegal activities and volunteers to go back to the tables undercover.
After releasing a salacious story about the director of the NSA, a reporter is murdered; Agent Simms comes back to help Carrie; Al reconnects with an ex who might be able to assist with the case.
Carrie and Al must uncover the pieces of a championship boxer's past to figure out who was able to beat him to death without any indication that he defended himself or fought back.
The Secret Service enlists Carrie and Al's help when a murder investigation leads them to uncover a counterfeiting ring run by an assassin.