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The CSI team is called in to investigate the stabbing of a couple found at a local motel that is reminiscent of two incidents that occurred in the same room.
When a man is found dead inside a human-sized hamster ball, the CSI team is brought in to investigate. Also, the team collaborates with a swing shift CSI on a case involving a serial rapist.
Spa weekend for Sara, Finlay and Morgan turns into a murder investigation and missing persons case when Finlay disappears, as the CSI team must piece together what happened in detail to find her.