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Grissom returns from his teaching sabbatical as Keppler tries to conceal his ties to a double murder case that he and his CSI colleagues are investigating.
Nick and Keppler's case leads them to uncover a black market for human body parts while the rest of the CSI team investigates the case of a wealthy married woman who was found murdered in her own home.
The miniature killer reveals he/she is still at large by sending Grissom an especially chilling miniature that forewarns a woman and her cat are scheduled to die the next day.