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As the CSI team comes closer than ever to identifying the miniature killer, Sara mysteriously goes missing, forcing her relationship with Grissom out into the open.
Sara's uneasy about Grissom being reunited with Lady Heather during the CSI's investigation of her attempted murder by a client she refuses to name.
The CSIs discover that several suspects in a woman's murder are members of a bizarre UFO club who believe that shape-shifting reptile-like aliens have mated with humans for centuries as a means of conquering the human race.
In their attempt to identify the murderer of a has-been boxer who lived among a group of prostitutes who detested him, the CSIs must establish which of several life-threatening acts against him in one night actually killed him.
While Grissom and the rest of the CSIs are out investigating new cases, Hodges leads Archie, Henry, Mandy and Wendy to believe that Grissom wants them to secretly band together that evening in an attempt to solve the four miniature killer cases.
Greg is forced to again contend with the hostile mother and brother of the hoodlum he killed in self-defense several months ago when the CSI team discovers that the brother is involved in a new murder case.
While processing the house where several showgirls were murdered, Sarah is haunted by the terrified eyes and cryptic dying words of the sixth victim she discovers.
Grissom and his team are discouraged when they find a pool of blood as they begin investigating the disappearance of a high school basketball star and his cheerleader girlfriend.
The miniature killer reveals he/she is still at large by sending Grissom an especially chilling miniature that forewarns a woman and her cat are scheduled to die the next day.
Grissom returns from his teaching sabbatical as Keppler tries to conceal his ties to a double murder case that he and his CSI colleagues are investigating.
Nick and Keppler's case leads them to uncover a black market for human body parts while the rest of the CSI team investigates the case of a wealthy married woman who was found murdered in her own home.
Catherine must deceive her teammates when she agrees to Keppler's covert and controversial plan to catch the killer of a popular politician.
Catherine and the rest of the CSI team find it challenging to get a good read on their new member as he joins them in tracking a recently active serial killer who has been killing since the 1970s.
Catherine is determined to connect an out-of-town killing to a recently released Las Vegas murder suspect in an attempt to bring him to justice.
Case involving a man killed at a poultry manufacturing plant leads the CSI team closer to discovering the identity of the serial killer who leaves miniature replicas of his crime scenes.
Grissom and his team investigate a string of murders in Las Vegas that may be tied to an infamous mob boss from the 1970s who disappeared many years ago.
When identical twins are found dead on the same night, the CSI team investigates whether or not the two murders are connected.
Grissom gets a chilling surprise when he receives another exact miniature replica of a working crime scene.
When two young boys are reported missing, Grissom goes head to head with a neighborhood pedophile in order to find them.
Grissom and his team investigate the case of a woman found dead in a parish church.
The CSI team investigates a series of brutal tourist beatings that take place within the span of a few hours throughout the Las Vegas area.
The deceased victims in the CSI coroner's office give voice to their own murder investigations for the first time.
Grissom is intrigued when he finds an exact miniature replica of a crime scene involving a famous ex-rock star.
When an aspiring dancer is murdered backstage during Cirque du Soleil's KA show, the CSIs investigate what goes on behind-the-scenes to uncover the truth.
After 15 seasons and more than 300 episodes, the CSI team of D.B. Russell, Sara Sidle, Greg Sanders, Dr. Albert Robbins, David Phillips, David Hodges, Morgan Brody and Henry Andrews welcome back Gil Grissom, Catherine Willows and Jim Brass for their final case, when they investigate a catastrophic event that paralyzes all of Las Vegas. Russell and Sidle will make decisions regarding their crime-fighting careers, and the return of Lady Heather will create controversy one last time between Grissom and Sidle.