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Sara's uneasy about Grissom being reunited with Lady Heather during the CSI's investigation of her attempted murder by a client she refuses to name.
The CSIs discover that several suspects in a woman's murder are members of a bizarre UFO club who believe that shape-shifting reptile-like aliens have mated with humans for centuries as a means of conquering the human race.
As the CSI team comes closer than ever to identifying the miniature killer, Sara mysteriously goes missing, forcing her relationship with Grissom out into the open.