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The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks.
When a woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment after a night of partying, Thirteen accompanies the woman to Princeton-Plainsboro where House and the team take on her case. Meanwhile, House keeps his private investigator, Lucas hot on Wilson's trail.
When an agoraphobic man falls mysteriously ill and adamantly refuses to leave his home to get treatment at the hospital, House and the team go to him to figure out what might be wrong.
Wilson slowly starts to recover from Amber's untimely death, but begins to reevaluate his life and to contemplate resigning from his post at the hospital. House's original regret over his role in Amber's death seems to have worn off as instead of being supportive, he merely tries to convince Wilson that he is overreacting to the situation. However, Wilson winds up leaving his post.