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When an agoraphobic man falls mysteriously ill and adamantly refuses to leave his home to get treatment at the hospital, House and the team go to him to figure out what might be wrong.
The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks.
The team takes on the case of a 16-year-old factory manager who fell ill when her lungs suddenly filled with fluid while at work. Meanwhile, Foreman asks for House's permission to work on a clinical trial and House rejects his proposal. In an effort to prove himself capable of working without House's supervision, Foreman takes on his own pediatric case. But when the unexplained illness brings the child to the brink of death, Foreman is left questioning his ability to work free from House's custody.
Wilson slowly starts to recover from Amber's untimely death, but begins to reevaluate his life and to contemplate resigning from his post at the hospital. House's original regret over his role in Amber's death seems to have worn off as instead of being supportive, he merely tries to convince Wilson that he is overreacting to the situation. However, Wilson winds up leaving his post.