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The team takes on the case of a high school senior who inexplicably blacks out during a class field trip and repeatedly hallucinates. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.
House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors, and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Wilson and House discover secrets about each other.
Princeton Plainsboro goes on lockdown when a newborn disappears from the nursery, preventing anyone from entering, leaving, or moving within the hospital. While House and his team members are trapped in various parts of the building, new insights surface about the team's personal lives, relationships, and regrets. Chase and Cameron finalize their divorce.
After finally realizing that his Vicodin habit is distorting his view of reality, House voluntarily enters Mayfield Psychiatric Hospital to detox. However, detoxing turns out to be the easy part - House can't get his medical license back until he's willing to admit his problems run deeper. Although he resists at first, he finally gives in. At the same time, he falls in love, but then finds his paramour has no further interest in him. When he turns to his doctor instead of Vicodin for help, Dr. Nolan realizes he's ready to return to the practice of medicine.