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House begins a detox program at Mayfield Psychiatric Hospital to get the Vicodin out of his system in an attempt to control his hallucinations.
House returns home to Princeton, where he continues to focus on his recovery but surprises Cuddy with the news that he's making a big change in his life. He's resigning. Meanwhile, the team cannot diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors. Foreman angles for House's job, but the pressure to solve the case creates tension in his relationship with Thirteen. Taub quits when he learns that House isn't returning and begins searching for a new job.
After finally realizing that his Vicodin habit is distorting his view of reality, House voluntarily enters Mayfield Psychiatric Hospital to detox. However, detoxing turns out to be the easy part - House can't get his medical license back until he's willing to admit his problems run deeper. Although he resists at first, he finally gives in. At the same time, he falls in love, but then finds his paramour has no further interest in him. When he turns to his doctor instead of Vicodin for help, Dr. Nolan realizes he's ready to return to the practice of medicine.