After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. Meanwhile, Cuddy and Wilson attend a medical conference for pharmacology and public policy. House tags along, planning to use the outing as an opportunity to push a personal agenda, but things don't go as expected.

On the eve of Thanksgiving, House and the team treat James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. A myriad of strange symptoms nearly stumps the doctors. Also, they wrestle with strained personal relationships. Cameron left Chase to live in Chicago.