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Holmes and Watson consult on a case in which a man suspected of murdering his wife years ago receives a ransom demand for her safe return. Meanwhile, Lestrade overstays his welcome at the brownstone and seems unwilling to leave.
Tensions rise when Holmes and Watson are forced to partner with Gareth Lestrade, Sherlock's former Scotland Yard colleague, on a bombing investigation.
When a famous cancer researcher is found dead, Holmes and Watson must determine if the scientist's untimely demise was tied to his latest cutting-edge invention. Meanwhile, Bell is finally cleared to re-enter the field.
In Season Two, the pair has made a name for themselves as a successful crime-solving duo that can crack the NYPD's most impossible cases. They'll return to solve mysteries from the past, get mixed up with the mob, and come face to face with their greatest adversaries.